Mladen pioneered tracer methods providing a corner stone for quantifying hormonal interactions in glucoregulation and pathogenesis diabetes. His hypothesis about beneficial or deleterious glucoregulatory effects of exercise in diabetes is universally accepted and is the basis of the concept that exercise not only ameliorates, but also prevents diabetes. He was the first to outline molecular mechanisms of hypothalamic pituitary adrenal dysfunction in diabetes, hypoglycemia and stress. He discovered new mechanisms how muscle, liver and pancreatic ?-cells adapt to hyperglycemia; a critical concept in diabetes. He provided that first evidence of glucagon’s extra pancreatic site; first evidence that one pancreatic hormone is synthesized outside of the pancreas. A large number of his students, fellows, and younger colleagues have become leaders in the field of diabetes research and treatment. Quote from CDA: The global diabetes family of patients, health professionals, scientists and policy makers has much to thank Mladen for. He has been a leading advocate in the advancement of diabetes research and had major national and international recognition for his basic and clinical research.