Mladen pioneered tracer methods providing a corner stone for quantifying hormonal interactions in glucoregulation and pathogenesis diabetes. His hypothesis about beneficial or deleterious glucoregulatory effects of exercise in diabetes is universally accepted and is the basis of the concept that exercise not only ameliorates, but also prevents diabetes. He was the first to outline molecular mechanisms of hypothalamic pituitary adrenal dysfunction in diabetes, hypoglycemia and stress. He discovered new mechanisms how muscle, liver and pancreatic ?-cells adapt to hyperglycemia; a critical ...