Salim Yusuf is a Professor of Medicine and Clinical Epidemiology and Biostatistics at McMaster University and Director of the Population Health Research Institute. As a Rhodes Scholar, he initiated the concept of large simple trials, coordinating the first ISIS trial and developing concepts of meta-analysis. Subsequently, he has applied these principles to several other areas that led to the SOLVD and DIG trials in heart failure while at the US NIH, and more recently the HOPE, OASIS, CURE and CREATE trials since his move to McMaster University, Canada. He holds a Heart and Stroke Foundation ...