Brian MacVicar is a superb electrophysiologist and a pioneer in the development and application of cellular imaging to models of normal and pathological brain function. His fundamental contributions have advanced knowledge about cell excitability, synaptic transmission, glial cell function, and neuronal trauma. Most importantly, his research has direct application to topics of immense clinical relevance, including stroke, epilepsy, and Alzheimer’s disease. He has established local and international research partnerships, provide an exemplary training environment, and shown tremendous leadership within the neuroscience community. He is recognized internationally as one of Canada’s most creative, original, and outstanding neuroscientists.