Michael Sole is Professor of Medicine and Physiology at the University of Toronto. He was Chief of Cardiology, at the now University Health Network from 1989-1998. He founded and directed The Centre for Cardiovascular Research from 1988-1999 and led its evolution into the Heart and Stroke/Richard Lewar Centre of Excellence at the University of Toronto. He was the first to map brain neurochemical changes in heart attack and failure. With Dr. C.C. Liew, he was the first to determine the genetic code for the human cardiac myosin heavy chain genes and mutations in myosin binding protein C in familial hypertrophic cardiomyopathy; they also developed the first genetic test for viral infection of the heart. His laboratory is currently recognized for pioneering molecular studies of cardiovascular diurnal rhythms.