Drug use contributes significantly to morbidity and mortality in Canada and worldwide. Dr Bruneau’s work centers on advancing best practices to enhance wellbeing and prevent HIV, hepatitis C, and other harms among people who use drugs. Her research has contributed to a better understanding of factors impeding and facilitating efforts to reduce HIV and hepatitis C transmission in this population and to the implementation and evaluation of novel interventions supporting equitable access to quality health care. A clinician and a researcher, Dr. Bruneau’s accomplishments have transformed harm reduction and drug use disorder practices, programs, and policies both locally and internationally.