Evangelos Michelakis is a clinician scientist internationally recognized for his translational research that has significantly advanced our understanding of complex and diverse diseases like pulmonary hypertension and cancer. His work on a novel role of Viagra in the treatment of pulmonary hypertension has affected clinical practice world-wide. His discoveries that mitochondria, the energy producing units in cells, can be novel targets for therapy in both pulmonary hypertension and cancer have been published is some of medicine's most prestigious journals and have changed the way we approach these deadly diseases, opening exciting new windows for effective therapies.