About Me
Dr. Borchers is an internationally recognized proteomics researcher. His research interests are mass spectrometry (MS)-based structural proteomics, quantitative proteomics, and metabolomics -- for biomedical and clinical applications. He uses crosslinkers to determine drug binding sites, protein protein interaction sites, and protein conformation, and has developed "top-down" structural methods for studying protein misfolding, a key factor in "mad-cow" disease, Alzheimer's', and Parkinson's. His research in multiple reaction monitoring involves the use of proven stable-isotope labeled peptides. The resulting highly-multiplexed methods are being developed for biomarker validation and clinical diagnostics in clinics. His pioneering work in MS-based metabolomics includes MS-based molecular imaging techniques.